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首页> 外文OA文献 >Lymphocyte proliferative responses to chlamydial antigens in human chlamydial eye infections.
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Lymphocyte proliferative responses to chlamydial antigens in human chlamydial eye infections.

机译：人衣原体眼感染中对衣原体抗原的淋巴细胞增殖反应。

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摘要

In order to study the relationship between cell-mediated immune responses to Chlamydia trachomatis and the pathogenesis of human chlamydial eye disease, we have measured the peripheral blood lymphocyte proliferative responses to whole chlamydial elementary bodies in 40 subjects with oculogenital chlamydial infection of varying severity, 13 subjects with genital chlamydial infections and 12 healthy seronegative controls. The mean stimulation index was significantly higher in those with oculogenital infections than in controls. There was a strong correlation between the response to C. trachomatis serotypes B and L1. We studied the relationship between proliferative responses and four clinical parameters: follicular conjunctivitis, papillary hypertrophy, corneal pannus and epithelial punctate keratitis, but were unable to show a significant association with any of these. Nor was there any association between proliferative response and serum antibody titre to C. trachomatis (pooled serotypes D-K), duration of disease or quantitative isolation of chlamydia from the conjunctiva. The depletion of CD8+ cells had no consistent effect on proliferative responses to serotype L1 in 13 subjects.
机译：为了研究对沙眼衣原体的细胞介导的免疫反应与人类衣原体眼病发病机制之间的关系，我们测量了40名不同程度的眼生殖器衣原体感染患者的外周血淋巴细胞对整个衣原体基本体的增殖反应，13生殖器衣原体感染的受试者和12位健康的血清阴性对照。眼源性感染者的平均刺激指数明显高于对照组。对沙眼衣原体血清型B和L1的反应之间存在很强的相关性。我们研究了增生反应与四个临床参数之间的关系：滤泡性结膜炎，乳头状肥大，角膜nu和上皮点状角膜炎，但未能显示出与这些因素之间的显着相关性。增殖反应与沙眼衣原体血清抗体滴度（合并血清型D-K），疾病持续时间或从结膜定量分离衣原体之间也没有任何联系。 CD13 +细胞的耗竭对13名受试者对L1型血清的增殖反应没有持续的影响。

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